LOSARTAN POTASSIUM + AMLODIPINE ) is a combination of an angiotensin II receptor (type AT1) antagonist and a calcium channel blocker. LOSARTAN POTASSIUM + AMLODIPINE has been shown to be effective in lowering blood pressure. Both losartan and amlodipine lower blood pressure by reducing peripheral resistance. Calcium influx blockade and reduction of angiotensin II vasoconstriction are complementary mechanisms.
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